TL;DR — Sermorelin, CJC-1295 with DAC, and CJC-1295 without DAC are three synthetic analogues of the endogenous 44-amino-acid peptide GHRH. They differ in length, half-life, and the GH-release pattern they produce. This guide compares them side by side for researchers choosing between them. B.A.B.E LABS stocks Sermorelin (AGELESS 10mg) and CJC-1295 (No DAC) as part of the HULK blend.
The three GHRH analogues at a glance:
| Sermorelin | CJC-1295 No DAC | CJC-1295 with DAC |
| Length | 29 aa (GHRH 1-29) | 30 aa (modified) | 30 aa + albumin-binding linker |
| Half-life | ~10–15 min | ~30 min | Multiple days |
| GH-release pattern | Pulsatile, brief | Pulsatile, slightly extended | Sustained elevation |
| Most-studied research context | Short-pulse GHRH-R stimulation | Pulse-timing research paired with GHSR agonists | Sustained-exposure models |
What Sermorelin is:
Sermorelin is the first 29 amino acids of native GHRH — the shortest fragment that retains full biological activity at the GHRH receptor on pituitary somatotrophs. It was the earliest GHRH analogue to be investigated across decades of endocrinology research.
Because Sermorelin has a short native half-life, research applications typically focus on short-pulse GHRH-R stimulation — useful in models where you want a clean, time-resolved signal from the GHRH pathway without chronic exposure.
What CJC-1295 (No DAC) is:
CJC-1295 without DAC — also called Mod GRF 1-29 — is a modified version of the GHRH 1-29 sequence with four amino acid substitutions that improve stability. It does not have the DAC (Drug Affinity Complex) modification.
The result: the peptide survives longer in circulation than Sermorelin (~30 minutes vs ~10–15 minutes) but still produces pulsatile GH release — not sustained elevation. This preserves the endogenous pulse pattern of the somatotropic axis, which is why it is the form used in dual-pathway research (paired with a GHSR agonist like Ipamorelin).
What CJC-1295 with DAC is:
The DAC version adds a maleimide group that covalently binds to serum albumin. Because albumin has a multi-day serum half-life, DAC-bound CJC-1295 stays in circulation for days rather than minutes.
This flattens the pulse pattern into a sustained GHRH-receptor exposure. Research that uses this form typically studies:
- Chronic exposure models — what happens when somatotrophs receive continuous GHRH-R stimulation rather than pulses?
- Downregulation/tachyphylaxis research — does sustained exposure blunt response?
- Convenience dosing models — fewer administrations per experimental timeline
B.A.B.E LABS does not currently stock the DAC form. The Hulk blend uses the No DAC form specifically because the goal of the blend is dual-pathway pulsatile activation.
Choosing between them:
Use Sermorelin research protocols when: you want the cleanest, shortest GHRH-R pulse; you're modelling native pulsatile GHRH release; or you're studying the acute-phase GH secretory response.
Use CJC-1295 No DAC protocols when: you want a slightly extended pulse but still within the pulsatile framework; you're pairing with a GHSR agonist for dual-pathway research see CJC-1295 + Ipamorelin Australia: GH Pulse Research Stack Guide.
Use DAC-modified protocols when: you need chronic / sustained GHRH-R activation — and note that this changes the biology materially versus either pulsatile form.
Why B.A.B.E LABS stocks Sermorelin and No-DAC:
The pulsatile forms are the more broadly studied research tools across published physiology, endocrinology, and sports-science literature. They are also more forgiving in experimental design — short half-life means easier washout between conditions, cleaner time-series data.
The DAC form is valuable for specific chronic-exposure questions, but it is a narrower research tool.
Storage, reconstitution, purity:
Identical protocol for all three analogues -
- Lyophilised: –20°C, light-protected
- Reconstituted: 2–8°C per COA window
- Purity: ≥99% (HPLC-tested)
Where these peptides appear in the catalogue:
- AGELESS
- HULK
- ADONIS bundle
- GLADIATOR bundle
- IMMORTAL bundle
Research-use disclaimer:
All three peptides are supplied strictly for in-vitro and laboratory research. Not TGA-approved. Not for human consumption.